MAML1 antibody

Catalog No. ABIN7116076

This Rabbit Polyclonal antibody specifically detects MAML1 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MAML1 antibody (ABIN7116076)

Target: MAML1 (Mastermind-Like 1 (MAML1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAML1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-MAML1 Antibody

Purpose: MAML1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: mastermind-like 1(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MAML1

Target: MAML1 (Mastermind-Like 1 (MAML1))

Alternative Name: MAML1

Background:

Synonyms: Mastermind-like protein 1 (Mam-1)|MAML1|KIAA0200

Background: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Molecular Weight: 108-120 kDa

Gene ID: 9794

UniProt: Q92585

Pathways: Notch Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development