MCM2 antibody

Catalog No. ABIN7116310

This Mouse Monoclonal antibody specifically detects MCM2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for MCM2 antibody (ABIN7116310)

Target: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MCM2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 4E3

Product Details anti-MCM2 Antibody

Purpose: MCM2 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: minichromosome maintenance complex component 2

Isotype: IgG2a

Application Details

Application Notes: WB: 1:1000-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MCM2

Target: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Alternative Name: MCM2

Background:

Synonyms: DNA replication licensing factor MCM2|Minichromosome maintenance protein 2 homolog|Nuclear protein BM28|MCM2|BM28|CCNL1|CDCL1|KIAA0030

Background: Acts as component of the MCM2-7 complex(MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.

Molecular Weight: 116-125 kDa

Gene ID: 4171

UniProt: P49736

Pathways: DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA