MLXIP antibody

Catalog No. ABIN7116474

The Rabbit Polyclonal anti-MLXIP antibody (ABIN7116474) specifically detects MLXIP in ELISA, WB, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MLXIP antibody (ABIN7116474)

Target: MLXIP (MLX Interacting Protein (MLXIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLXIP antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MLXIP Antibody

Purpose: MLXIP antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: MLX interacting protein

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MLXIP

Target: MLXIP (MLX Interacting Protein (MLXIP))

Alternative Name: MLXIP

Background:

Synonyms: MLX-interacting protein|Class E basic helix-loop-helix protein 36 (bHLHe36)|Transcriptional activator MondoA|MLXIP|BHLHE36|KIAA0867|MIR|MONDOA

Background: Mlx-interacting protein(MLXIP), after forming heterodimers with MLX, can bind to and then activate transcription from CACGTG E boxes. The N terminus of MLXIP acts as a CRM1-dependent nuclear export signal and contribute to the cytoplasmic localization of the complex, and as a binding site for 13 protein. the C terminus contains a cytoplasmic localization signal and mediates protein-protein interaction of MONDOA and MLX. The complex play a role in transcriptional activation of glycolytic target genes and glucose-responsive gene regulation. This antibody could recognize isoform1(~110kd) and isoform3(~69kd) of MLXIP. A specific MLXIP of approximately 130 kDa was detected. It demonstrates that MLXIP associated specifically with Mlx in the cytoplasm (PMID: 11073985).

Molecular Weight: 130 kDa

Gene ID: 22877

UniProt: Q9HAP2