MYO9B antibody

Catalog No. ABIN7116615

This anti-MYO9B antibody is a Rabbit Polyclonal antibody detecting MYO9B in WB, ELISA and IP. Suitable for Human, Mouse and Rat.

Quick Overview for MYO9B antibody (ABIN7116615)

Target: MYO9B (Myosin IXB (MYO9B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYO9B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-MYO9B Antibody

Purpose: MYO9B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: myosin IXB

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MYO9B

Target: MYO9B (Myosin IXB (MYO9B))

Alternative Name: MYO9B

Background:

Synonyms: Unconventional myosin-IXb|Unconventional myosin-9b|MYO9B|MYR5

Background: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions(PubMed:9490638). Also acts as a GTPase activator for RHOA(PubMed:9490638, PubMed:26529257). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1, interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA(PubMed:26529257).

Molecular Weight: 230-250 kDa

Gene ID: 4650

UniProt: Q13459