NLRX1 antibody

Catalog No. ABIN7116905

The Rabbit Polyclonal anti-NLRX1 antibody is suitable to detect NLRX1 in samples from Human, Rat and Mouse. It has been validated for WB, ELISA, IHC, IF and IP.

Quick Overview for NLRX1 antibody (ABIN7116905)

Target: NLRX1 (NLR Family Member X1 (NLRX1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRX1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-NLRX1 Antibody

Purpose: NLRX1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: NLR family member X1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:500-1:1000, IHC: 1:50-1:500, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for NLRX1

Target: NLRX1 (NLR Family Member X1 (NLRX1))

Alternative Name: NLRX1

Background:

Synonyms: NLR family member X1|Caterpiller protein 11.3 (CLR11.3)|Nucleotide-binding oligomerization domain protein 5|Nucleotide-binding oligomerization domain protein 9|NLRX1|NOD5|NOD9

Background: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH(RIG-like helicase)-MAVS interaction(PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species(PubMed:18219313).

Molecular Weight: 110 kDa

Gene ID: 79671

UniProt: Q86UT6

Pathways: SARS-CoV-2 Protein Interactome