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NUMBL antibody

NUMBL Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IP, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7117091
  • Target See all NUMBL Antibodies
    NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
    Reactivity
    • 46
    • 8
    • 8
    • 1
    Human, Mouse, Rat
    Host
    • 44
    • 1
    • 1
    Rabbit
    Clonality
    • 45
    • 1
    Polyclonal
    Conjugate
    • 11
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NUMBL antibody is un-conjugated
    Application
    • 31
    • 21
    • 15
    • 13
    • 13
    • 5
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    numb homolog(Drosophila)-like
    Isotype
    IgG
    Top Product
    Discover our top product NUMBL Primary Antibody
  • Application Notes
    WB: 1:500-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
    Alternative Name
    NUMBL (NUMBL Products)
    Synonyms
    nbl antibody, numb antibody, cag3a antibody, ctg3a antibody, numbr antibody, numb-r antibody, tnrc23 antibody, numblike antibody, CAG3A antibody, CTG3a antibody, NBL antibody, NUMB-R antibody, NUMBLIKE antibody, NUMBR antibody, TNRC23 antibody, NUMB like, endocytic adaptor protein antibody, numb homolog-like L homeolog antibody, NUMB-like, endocytic adaptor protein antibody, numb-like antibody, NUMBL antibody, numbl.L antibody, Numbl antibody
    Background
    Synonyms: Background:Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
    Molecular Weight
    65-70 kDa
    Gene ID
    9253
    UniProt
    Q9Y6R0
    Pathways
    Cell-Cell Junction Organization
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