OTUD7B antibody

Catalog No. ABIN7117156

This Rabbit Polyclonal antibody specifically detects OTUD7B in ELISA, WB, IHC and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for OTUD7B antibody (ABIN7117156)

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OTUD7B antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-OTUD7B Antibody

Purpose: OTUD7B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: OTU domain containing 7B

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for OTUD7B

Target: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Alternative Name: OTUD7B

Background:

Synonyms: OTU domain-containing protein 7B|Cellular zinc finger anti-NF-kappa-B protein (Cezanne)|Zinc finger A20 domain-containing protein 1|Zinc finger protein Cezanne|OTUD7B|ZA20D1

Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. In vitro, has preference for 'Lys-11'-linked polyubiquitin chains, however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.

Molecular Weight: 100 kDa

Gene ID: 56957

UniProt: Q6GQQ9