PPIL2 antibody

Catalog No. ABIN7117300

This Rabbit Polyclonal antibody specifically detects PPIL2 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PPIL2 antibody (ABIN7117300)

Target: PPIL2 (Peptidylprolyl Isomerase (Cyclophilin)-Like 2 (PPIL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPIL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PPIL2 Antibody

Purpose: PPIL2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: peptidylprolyl isomerase(cyclophilin)-like 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PPIL2

Target: PPIL2 (Peptidylprolyl Isomerase (Cyclophilin)-Like 2 (PPIL2))

Alternative Name: PPIL2

Background:

Synonyms: RING-type E3 ubiquitin-protein ligase PPIL2|CYC4|Cyclophilin-60 (Cyclophilin-like protein Cyp-60, Cyp60, hCyP-60)|Probable inactive peptidyl-prolyl cis-trans isomerase-like 2 (PPIase)|Rotamase PPIL2|PPIL2

Background: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins(By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance(PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation(PubMed:11435423).

Molecular Weight: 59 kDa

Gene ID: 23759

UniProt: Q13356