Gastrin-Releasing Peptide antibody (AA 1-148)

Catalog No. ABIN7117775

The Rabbit Polyclonal anti-Gastrin-Releasing Peptide antibody has been validated for ELISA, WB and IHC. It is suitable to detect Gastrin-Releasing Peptide in samples from Human.

Quick Overview for Gastrin-Releasing Peptide antibody (AA 1-148) (ABIN7117775)

Target: Gastrin-Releasing Peptide (GRP)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Gastrin-Releasing Peptide antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Gastrin-Releasing Peptide Antibody

Binding Specificity: AA 1-148

Purpose: GRP antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-148aa

Immunogen: gastrin-releasing peptide

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Gastrin-Releasing Peptide

Target: Gastrin-Releasing Peptide (GRP)

Alternative Name: GRP

Background:

Synonyms: Gastrin-releasing peptide (GRP)|Neuromedin-C Alternative names: GRP-10|GRP18-27|GRP

Background: Gastrin-releasing peptide, also known as GRP, is normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets, and its main function is to stimulate secretion of HCl by the gastric mucosa. HCl, in turn, inhibits gastrin formation. Its 148-amino acid preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27-amino acid gastrin-releasing peptide or the 10-amino acid neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation.These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate.

Molecular Weight: 16 kDa, 32 kDa

Gene ID: 2922

UniProt: P07492

Pathways: Peptide Hormone Metabolism, Hormone Activity