PSMB1 antibody

Catalog No. ABIN7117906

This Rabbit Polyclonal antibody specifically detects PSMB1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PSMB1 antibody (ABIN7117906)

Target: PSMB1 (Proteasome (Prosome, Macropain) Subunit, beta Type, 1 (PSMB1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PSMB1 Antibody

Purpose: PSMB1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: proteasome (prosome, macropain) subunit, beta type, 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PSMB1

Target: PSMB1 (Proteasome (Prosome, Macropain) Subunit, beta Type, 1 (PSMB1))

Alternative Name: PSMB1

Background:

Synonyms: Proteasome subunit beta type-1|Macropain subunit C5|Multicatalytic endopeptidase complex subunit C5|Proteasome component C5|Proteasome gamma chain|PSMB1|PSC5

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species.

Molecular Weight: 23 kDa

Gene ID: 5689

UniProt: P20618

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA