PRMT5 antibody (AA 76-291)

Catalog No. ABIN7117928

The Rabbit Polyclonal anti-PRMT5 antibody has been validated for WB, IHC and ELISA. It is suitable to detect PRMT5 in samples from Human, Mouse, Rat and Monkey.

Quick Overview for PRMT5 antibody (AA 76-291) (ABIN7117928)

Target: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRMT5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PRMT5 Antibody

Binding Specificity: AA 76-291

Purpose: PRMT5 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 76-291aa

Immunogen: protein arginine methyltransferase 5

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PRMT5

Target: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Alternative Name: PRMT5

Background:

Synonyms: Protein arginine N-methyltransferase 5 (PRMT5)|72 kDa ICln-binding protein|Histone-arginine N-methyltransferase PRMT5|Jak-binding protein 1|Shk1 kinase-binding protein 1 homolog (SKB1 homolog, SKB1Hs)|Protein arginine N-methyltransferase 5, N-terminally processed|PRMT5|HRMT1L5|IBP72|JBP1|SKB1

Background: This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 70 kDa

Gene ID: 10419

UniProt: O14744

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Ribonucleoprotein Complex Subunit Organization, Skeletal Muscle Fiber Development