RASGRP2 antibody

Catalog No. ABIN7118303

The Rabbit Polyclonal anti-RASGRP2 antibody has been validated for WB and ELISA. It is suitable to detect RASGRP2 in samples from Human and Mouse.

Quick Overview for RASGRP2 antibody (ABIN7118303)

Target: RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASGRP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RASGRP2 Antibody

Purpose: RASGRP2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: RAS guanyl releasing protein 2(calcium and DAG-regulated)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RASGRP2

Target: RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))

Alternative Name: RASGRP2

Background:

Synonyms: RAS guanyl-releasing protein 2|Calcium and DAG-regulated guanine nucleotide exchange factor I (CalDAG-GEFI)|Cdc25-like protein (hCDC25L)|F25B3.3 kinase-like protein|RASGRP2|CDC25L|MCG7

Background: Functions as a calcium-and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.

Molecular Weight: 48 kDa

Gene ID: 10235

UniProt: Q7LDG7

Pathways: TCR Signaling