Retinoblastoma Binding Protein 8 antibody

Catalog No. ABIN7118434

This Rabbit Polyclonal antibody specifically detects Retinoblastoma Binding Protein 8 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Retinoblastoma Binding Protein 8 antibody (ABIN7118434)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma Binding Protein 8 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-Retinoblastoma Binding Protein 8 Antibody

Purpose: RBBP8 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: retinoblastoma binding protein 8

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Alternative Name: RBBP8

Background:

Synonyms: DNA endonuclease RBBP8|CtBP-interacting protein (CtIP)|Retinoblastoma-binding protein 8 (RBBP-8)|Retinoblastoma-interacting protein and myosin-like (RIM)|Sporulation in the absence of SPO11 protein 2 homolog (SAE2)|RBBP8|CTIP

Background: Endonuclease that cooperates with the MRE11-RAD50-NBN(MRN) complex in processing meiotic and mitotic double-strand breaks(DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining(A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.

Molecular Weight: 120 kDa

Gene ID: 5932

UniProt: Q99708

Pathways: Cell Division Cycle, DNA Damage Repair