SRRM1 antibody

Catalog No. ABIN7118908

This Rabbit Polyclonal antibody specifically detects SRRM1 in WB and ELISA. It exhibits reactivity toward Mouse, Human and Rat.

Quick Overview for SRRM1 antibody (ABIN7118908)

Target: SRRM1 (Serine/arginine Repetitive Matrix 1 (SRRM1))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRRM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SRRM1 Antibody

Purpose: SRRM1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: serine/arginine repetitive matrix 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SRRM1

Target: SRRM1 (Serine/arginine Repetitive Matrix 1 (SRRM1))

Alternative Name: SRRM1

Background:

Synonyms: Serine/arginine repetitive matrix protein 1|SR-related nuclear matrix protein of 160 kDa (SRm160)|Ser/Arg-related nuclear matrix protein|SRRM1|SRM160

Background: Part of pre-and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer(ESE)-dependent splicing activation by bridging together sequence-specific(SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP(SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double-or single-stranded nucleic acid substrates.

Molecular Weight: 120-160 kDa

Gene ID: 10250

UniProt: Q8IYB3