SETD7 antibody

Catalog No. ABIN7118988

The Rabbit Polyclonal anti-SETD7 antibody (ABIN7118988) specifically detects SETD7 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SETD7 antibody (ABIN7118988)

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETD7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SETD7 Antibody

Purpose: SETD7 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: SET domain containing(lysine methyltransferase) 7

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SETD7

Target: SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Alternative Name: SETD7

Background:

Synonyms: Histone-lysine N-methyltransferase SETD7|Histone H3-K4 methyltransferase SETD7 (H3-K4-HMTase SETD7)|Lysine N-methyltransferase 7|SET domain-containing protein 7|SET7/9|SETD7|KIAA1717|KMT7|SET7|SET9

Background: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Molecular Weight: 48-50 kDa

Gene ID: 80854

UniProt: Q8WTS6