SH3BP4 antibody (AA 615-963)

Catalog No. ABIN7119024

This anti-SH3BP4 antibody is a Rabbit Polyclonal antibody detecting SH3BP4 in WB, ELISA, IP and IF. Suitable for Human, Mouse and Rat.

Quick Overview for SH3BP4 antibody (AA 615-963) (ABIN7119024)

Target: SH3BP4 (SH3-Domain Binding Protein 4 (SH3BP4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH3BP4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Product Details anti-SH3BP4 Antibody

Binding Specificity: AA 615-963

Purpose: SH3BP4 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 615-963aa

Immunogen: SH3-domain binding protein 4

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SH3BP4

Target: SH3BP4 (SH3-Domain Binding Protein 4 (SH3BP4))

Alternative Name: SH3BP4

Background:

Synonyms: SH3 domain-binding protein 4|EH-binding protein 10|Transferrin receptor-trafficking protein|SH3BP4|BOG25|EHB10|TTP

Background: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.

Molecular Weight: 120 kDa

Gene ID: 23677

UniProt: Q9P0V3