SRGAP2 antibody (AA 780-940)

Catalog No. ABIN7119134

The Rabbit Polyclonal anti-SRGAP2 antibody has been validated for WB, ELISA and IHC. It is suitable to detect SRGAP2 in samples from Human, Mouse and Rat.

Quick Overview for SRGAP2 antibody (AA 780-940) (ABIN7119134)

Target: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRGAP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SRGAP2 Antibody

Binding Specificity: AA 780-940

Purpose: SRGAP2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 780-940aa

Immunogen: SLIT-ROBO Rho GTPase activating protein 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SRGAP2

Target: SRGAP2 (SLIT-ROBO rho GTPase Activating Protein 2 (SRGAP2))

Alternative Name: SRGAP2

Background:

Synonyms: SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2)|Formin-binding protein 2|Rho GTPase-activating protein 34|SRGAP2|ARHGAP34|FNBP2|KIAA0456|SRGAP2A

Background: RAC1 GTPase activating protein(GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.

Molecular Weight: 120-140 kDa

Gene ID: 23380

UniProt: O75044