SNAIL antibody

Catalog No. ABIN7119198

The Rabbit Polyclonal anti-SNAIL antibody (ABIN7119198) specifically detects SNAIL in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SNAIL antibody (ABIN7119198)

Target: SNAIL (SNAI1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SNAIL Antibody

Purpose: SNAI1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: snail homolog 1(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI1

Background:

Synonyms: Zinc finger protein SNAI1|Protein snail homolog 1 (Protein sna)|SNAI1|SNAH

Background: Involved in induction of the epithelial to mesenchymal transition(EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate(TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Molecular Weight: 29 kDa

Gene ID: 6615

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling