STEAP3 antibody

Catalog No. ABIN7119514

This Rabbit Polyclonal antibody specifically detects STEAP3 in WB, ELISA, IHC, IF and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for STEAP3 antibody (ABIN7119514)

Target: STEAP3 (STEAP Family Member 3, Metalloreductase (STEAP3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STEAP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-STEAP3 Antibody

Purpose: STEAP3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: STEAP family member 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for STEAP3

Target: STEAP3 (STEAP Family Member 3, Metalloreductase (STEAP3))

Alternative Name: STEAP3

Background:

Synonyms: Metalloreductase STEAP3|Dudulin-2|Six-transmembrane epithelial antigen of prostate 3|Tumor suppressor-activated pathway protein 6 (hTSAP6)| pH yde (h pH yde)|STEAP3|TSAP6

Background: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.

Molecular Weight: 55 kDa

Gene ID: 55240

UniProt: Q658P3

Pathways: Transition Metal Ion Homeostasis