SSRP1 antibody

Catalog No. ABIN7119562

This Rabbit Polyclonal antibody specifically detects SSRP1 in WB, IHC, ELISA and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for SSRP1 antibody (ABIN7119562)

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSRP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-SSRP1 Antibody

Purpose: SSRP1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: structure specific recognition protein 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SSRP1

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Alternative Name: SSRP1

Background:

Synonyms: FACT complex subunit SSRP1|Chromatin-specific transcription elongation factor 80 kDa subunit|Facilitates chromatin transcription complex 80 kDa subunit (FACT 80 kDa subunit, FACTp80)|Facilitates chromatin transcription complex subunit SSRP1|Recombination signal sequence recognition protein 1|Structure-specific recognition protein 1 (hSSRP1)|T160|SSRP1|FACT80

Background: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.

Molecular Weight: 90 kDa

Gene ID: 6749

UniProt: Q08945

Pathways: Chromatin Binding