TELO2 antibody

Catalog No. ABIN7119825

The Mouse Monoclonal anti-TELO2 antibody (Clone 8B6) (ABIN7119825) specifically detects TELO2 in WB, ELISA, IHC, IF and IP. The antibody is reactive with Human samples.

Quick Overview for TELO2 antibody (ABIN7119825)

Target: TELO2 (TEL2, Telomere Maintenance 2, Homolog (TELO2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TELO2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 8B6

Product Details anti-TELO2 Antibody

Purpose: TELO2 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: TEL2, telomere maintenance 2, homolog

Isotype: IgG2a

Application Details

Application Notes: WB: 1:1000-1:4000, IP: 1:500-1:1000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TELO2

Target: TELO2 (TEL2, Telomere Maintenance 2, Homolog (TELO2))

Alternative Name: TELO2

Background:

Synonyms: Telomere length regulation protein TEL2 homolog|Protein clk-2 homolog (hCLK2)|TELO2|KIAA0683

Background: Regulator of the DNA damage response(DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase(PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation(IR), ultraviolet(UV) and mitomycin C(MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.

Molecular Weight: 92 kDa

Gene ID: 9894

UniProt: Q9Y4R8