TEX14 antibody

Catalog No. ABIN7119846

The Rabbit Polyclonal anti-TEX14 antibody (ABIN7119846) specifically detects TEX14 in WB, ELISA, IHC and IP. The antibody is reactive with Human and Mouse samples.

Quick Overview for TEX14 antibody (ABIN7119846)

Target: TEX14 (Testis Expressed 14 (TEX14))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEX14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-TEX14 Antibody

Purpose: TEX14 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: testis expressed 14

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TEX14

Target: TEX14 (Testis Expressed 14 (TEX14))

Alternative Name: TEX14

Background:

Synonyms: Inactive serine/threonine-protein kinase TEX14|Protein kinase-like protein SgK307|Sugen kinase 307|Testis-expressed sequence 14|Testis-expressed sequence 14 protein|TEX14|SGK307

Background: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro(By similarity).

Molecular Weight: 180-200 kDa, 106 kDa

Gene ID: 56155

UniProt: Q8IWB6

Pathways: Maintenance of Protein Location