FAS antibody (AA 156-335)

Catalog No. ABIN7119981

This anti-FAS antibody is a Mouse Monoclonal antibody detecting FAS in WB, FACS, IHC and ELISA. Suitable for Human and Mouse.

Quick Overview for FAS antibody (AA 156-335) (ABIN7119981)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This FAS antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA

Clone: 4B6

Product Details anti-FAS Antibody

Binding Specificity: AA 156-335

Purpose: FAS antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 156-335aa

Immunogen: Fas(TNF receptor superfamily, member 6)

Isotype: IgG2a

Application Details

Application Notes: WB: 1:1000-1:8000, IHC: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Alternative Name: FAS

Background:

Synonyms: Tumor necrosis factor receptor superfamily member 6|Apo-1 antigen|Apoptosis-mediating surface antigen FAS|FASLG receptor|FAS|APT1|FAS1|TNFRSF6

Background: Fas(CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor(TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex(DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form(40-55 kDa) of Fas is due to glycosylation.

Molecular Weight: 38-45 kDa

Gene ID: 355

UniProt: P25445

Pathways: p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity