TRPC4AP antibody

Catalog No. ABIN7120129

This Mouse Monoclonal antibody specifically detects TRPC4AP in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for TRPC4AP antibody (ABIN7120129)

Target: TRPC4AP (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TRPC4AP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 1C0

Product Details anti-TRPC4AP Antibody

Purpose: TRPC4AP antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: transient receptor potential cation channel, subfamily C, member 4 associated protein

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TRPC4AP

Target: TRPC4AP (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP))

Alternative Name: TRPC4AP

Background:

Synonyms: Short transient receptor potential channel 4-associated protein (Trp4-associated protein, Trpc4-associated protein)|Protein TAP1|TNF-receptor ubiquitous scaffolding/signaling protein (Protein TRUSS)|TRPC4AP|C20orf188|TRRP4AP

Background: Substrate-specific adapter of a DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Molecular Weight: 91 kDa

Gene ID: 26133

UniProt: Q8TEL6