TNFAIP1 antibody

Catalog No. ABIN7120411

This Mouse Monoclonal antibody specifically detects TNFAIP1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for TNFAIP1 antibody (ABIN7120411)

Target: TNFAIP1 (Tumor Necrosis Factor, alpha-Induced Protein 1 (Endothelial) (TNFAIP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFAIP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 2H3

Product Details anti-TNFAIP1 Antibody

Purpose: TNFAIP1 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: tumor necrosis factor, alpha-induced protein 1(endothelial)

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000-1:6000, IHC: 1:50-1:600

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TNFAIP1

Target: TNFAIP1 (Tumor Necrosis Factor, alpha-Induced Protein 1 (Endothelial) (TNFAIP1))

Alternative Name: TNFAIP1

Background:

Synonyms: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2)|BTB/POZ domain-containing protein TNFAIP1|Protein B12|Tumor necrosis factor, alpha-induced protein 1, endothelial|TNFAIP1|BACURD2|EDP1

Background: Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Molecular Weight: 36 kDa

Gene ID: 7126

UniProt: Q13829