WDFY3 antibody

Catalog No. ABIN7120806

The Rabbit Polyclonal anti-WDFY3 antibody (ABIN7120806) specifically detects WDFY3 in ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for WDFY3 antibody (ABIN7120806)

Target: WDFY3 (WD Repeat and FYVE Domain Containing 3 (WDFY3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDFY3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-WDFY3 Antibody

Purpose: WDFY3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: WD repeat and FYVE domain containing 3

Isotype: IgG

Application Details

Application Notes: IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for WDFY3

Target: WDFY3 (WD Repeat and FYVE Domain Containing 3 (WDFY3))

Alternative Name: WDFY3

Background:

Synonyms: WD repeat and FYVE domain-containing protein 3|Autophagy-linked FYVE protein (Alfy)|WDFY3|KIAA0993

Background: Required for selective autophagy(aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies(p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.

Gene ID: 23001

UniProt: Q8IZQ1