YTHDC2 antibody (AA 1131-1430)

Catalog No. ABIN7120902

The Rabbit Polyclonal anti-YTHDC2 antibody (ABIN7120902) specifically detects YTHDC2 in WB, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for YTHDC2 antibody (AA 1131-1430) (ABIN7120902)

Target: YTHDC2 (YTH Domain Containing 2 (YTHDC2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YTHDC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-YTHDC2 Antibody

Binding Specificity: AA 1131-1430

Purpose: YTHDC2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1131-1430aa

Immunogen: 3'-5' RNA helicase YTHDC2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for YTHDC2

Target: YTHDC2 (YTH Domain Containing 2 (YTHDC2))

Alternative Name: YTHDC2

Background:

Synonyms: 3'-5' RNA helicase YTHDC2|YTH domain-containing protein 2 (hYTHDC2)|YTHDC2

Background: This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line.

Molecular Weight: 160 kDa

Gene ID: 64848

UniProt: Q9H6S0