YTHDC2 antibody (AA 1131-1430)

Catalog No. ABIN7271425

This Rabbit Polyclonal antibody specifically detects YTHDC2 in WB. It exhibits reactivity toward Human.

Quick Overview for YTHDC2 antibody (AA 1131-1430) (ABIN7271425)

Target: YTHDC2 (YTH Domain Containing 2 (YTHDC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YTHDC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-YTHDC2 Antibody

Binding Specificity: AA 1131-1430

Purpose: YTHDC2 Rabbit pAb

Sequence: HSLFLRRMRA PSKPWSQVDE ATIRAIIAVL STEEQSAGLQ QPSGIGQRPR PMSSEELPLA SSWRSNNSRK SSADTEFSDE CTTAERVLMK SPSPALHPPQ KYKDRGILHP KRGTEDRSDQ SSLKSTDSSS YPSPCASPSP PSSGKGSKSP SPRPNMPVRY FIMKSSNLRN LEISQQKGIW STTPSNERKL NRAFWESSIV YLVFSVQGSG HFQGFSRMSS EIGREKSQDW GSAGLGGVFK VEWIRKESLP FQFAHHLLNP WNDNKKVQIS RDGQELEPLV GEQLLQLWER LPLGEKNTTD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1131-1430 of human YTHDC2 (NP_073739.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for YTHDC2

Target: YTHDC2 (YTH Domain Containing 2 (YTHDC2))

Alternative Name: YTHDC2

Background: This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016],YTHDC2;CAHL,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,YTHDC2

Molecular Weight: 160kDa

Gene ID: 64848

UniProt: Q9H6S0