DMRT2 antibody

Catalog No. ABIN7504176

Product Details anti-DMRT2 Antibody

Target: DMRT2 (Doublesex and Mab-3 Related Transcription Factor 2 (DMRT2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DMRT2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificity: The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity).

Cross-Reactivity (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human DMRT2 protein

Isotype: IgG2b

Application Details

Application Notes:

Positive Control: HeLa or MCF-7 cells.

Known Application: Flow Cytometry (1-2 μg/million cells), ,Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.

Expiry Date: 24 months

Target Details for DMRT2

Target: DMRT2 (Doublesex and Mab-3 Related Transcription Factor 2 (DMRT2))

Alternative Name: DMRT2 (DMRT2 Products)

Synonyms: dmrt2 antibody, zDmrt2 antibody, Terra antibody, DMRT2 antibody, dmrt2a antibody, MGC131063 antibody, Terra-like antibody, Ci-DMRT2 antibody, doublesex and mab-3 related transcription factor 2 antibody, doublesex and mab-3 related transcription factor 2a antibody, doublesex and mab-3 related transcription factor 2 L homeolog antibody, doublesex and mab-3 related transcription factor 2b antibody, DMRT2 antibody, dmrt2a antibody, Dmrt2 antibody, dmrt2 antibody, dmrt2.L antibody, LOC778577 antibody, dmrt2b antibody

Background: Doublesex and mab-3 related transcription factor 2, doublesex-like 2 protein (DSXL-2), terra like protein antibody,DMRT2 (Transcription Factor)
Cellular localisation: Nucleus

Molecular Weight: 62kDa

Gene ID: 10655, 59506

UniProt: Q9Y5R5