ETS2 antibody

Catalog No. ABIN7126356

The Mouse Monoclonal anti-ETS2 antibody is suitable to detect ETS2 in samples from Human. It has been validated for ELISA, IF and FACS.

Quick Overview for ETS2 antibody (ABIN7126356)

Target: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ETS2 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-ETS2-1D9

Product Details anti-ETS2 Antibody

Purpose: ETS2 (Transcription Factor) Antibody

Specificity: ETS2 (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. ETS2 was shown to be mutated in reeler mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. ETS2 protein expression is complex and changes throughout development. ETS2 appears to function upstream of Dab1, in a signaling pathway that controls cell positioning in the developing brain, and is also thought to be a direct effector of the neurotrophin BDNF.

Cross-Reactivity (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human ETS2 protein

Isotype: IgG2b

Application Details

Application Notes:

Known_Application: ELISA (For coating, order antibody without BSA), ,Flow Cytometry (1-2 μg/million cells),Immunofluorescence (1-2 μg/mL), ,Immunoprecipitation (1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)), ,Optimal dilution for a specific application should be determined.

Positive_Control: Human thymus, lung or cerebellum.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for ETS2

Target: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Alternative Name: ETS2

Background:

C ets 2 protein, ETS2, ETS2IT1, Oncogene ETS2, Protein C-ets-2, v ets avian erythroblastosis virus E2 oncogene homolog 2, V ets avian erythroblastosis virus E26 oncogene homolog 2

Human thymus, lung or cerebellum.

Molecular Weight: 52kDa

Gene ID: 2114, 644231

UniProt: P15036

Pathways: EGFR Signaling Pathway, Myometrial Relaxation and Contraction