APOA4 antibody (AA 239-371)

Catalog No. ABIN7126528

Product Details anti-APOA4 Antibody

Target: APOA4 (Apolipoprotein A-IV (APOA4))

Binding Specificity: AA 239-371

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOA4 antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: Apolipoproteins are protein components of plasma lipoproteins. The human apoA-I gene encodes a single chain, 243 amino acid protein which promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. It can function as a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for the formation of most plasma cholesteryl esters. The human apoA-II gene encodes the second most abundant protein of HDL particles, where it influences plasma levels of free fatty acids (FFA). The human apoA-IV gene encodes a 396 amino acid preprotein, which after proteolytic processing is secreted from the intestine in association with chylomicron particles. ApoA-IV is a potent activator of LCAT in vitro. The human apoA-V gene encodes a 366 amino acid protein that is believed to be an important determinant of plasma triglyceride levels.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Human recombinant APOA4 protein fragment (around aa 239-371) (exact sequence is proprietary)

Isotype: IgG2b

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human ovarian cancer and cervical cancer tissues.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for APOA4

Target: APOA4 (Apolipoprotein A-IV (APOA4))

Alternative Name: APOA4 (APOA4 Products)

Synonyms: Apo-AIV antibody, ApoA-IV antibody, apoAIV antibody, APOAIV antibody, APOA4 antibody, myh11 antibody, Apoa-4 antibody, apolipoprotein A4 antibody, apolipoprotein A4 L homeolog antibody, apolipoprotein A-IV antibody, apolipoprotein A-IV a antibody, APOA4 antibody, Apoa4 antibody, apoa4 antibody, apoa4.L antibody, apoa4a antibody

Background: ApoA4, Apolipoprotein A-IV,Apolipoprotein A4 / apoA-IV
Cellular localisation: Secreted.

Molecular Weight: 46kDa

Gene ID: 337, 1247

UniProt: P06727

Pathways: Lipid Metabolism