Recombinant Inhibin alpha antibody (AA 233-362)

Catalog No. ABIN7126593

The Mouse Monoclonal anti-Inhibin alpha antibody is suitable to detect Inhibin alpha in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant Inhibin alpha antibody (AA 233-362) (ABIN7126593)

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Inhibin alpha antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: RINHA-6919

Product Details anti-Inhibin alpha Antibody

Binding Specificity: AA 233-362

Purpose: Recombinant Inhibin, alpha (INHA) (Gonadal Cell Marker) Antibody

Specificity: It recognizes a 47 kDa protein, which is identified as alpha sub-unit of Inhibin. It is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises two subunits, Inhibin A and Inhibin B. Each subunit consists of the same °™ subunit, covalently linked to 1 of 2 distinct subunits, æ-°™ or æ- æ. Originally isolated from ovarian follicular fluid and characterized as a disulphide-linked dimeric glycoprotein, inhibin belongs to the transforming growth factor æ (TFG æ) superfamily. Antibodies against Inhibin are useful in making a differentiation between adrenal cortical tumors and renal cell carcinoma. Sex cord stromal tumors of the ovary as well as trophoblastic tumors also demonstrate cytoplasmic positivity. Inhibin antibody is also used to make the differential diagnosis of intra-uterine vs. ectopic pregnancy in endometrial curetting.

Cross-Reactivity (Details): Human.

Purification: 200ug/ml of Ab produced in HEK293 cell mammalian-based expression system.

Immunogen: Recombinant fragment of human Inhibin alpha protein (around aa 233-362) (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human prostate or testis.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Inhibin alpha

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Alternative Name: INHA

Background:

A inhibin subunit, IHA, inhA, Inhibin alpha chain, Inhibin alpha subunit

Human prostate or testis.

Molecular Weight: 47kDa

Gene ID: 3623, 407506

UniProt: P05111

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion