TTR antibody

Catalog No. ABIN7127027

This anti-TTR antibody is a Mouse Monoclonal antibody detecting TTR in WB and IHC (f). Suitable for Human.

Quick Overview for TTR antibody (ABIN7127027)

Target: TTR (Transthyretin (TTR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TTR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Product Details anti-TTR Antibody

Specificity: Prealbumin, also designated transthyretin, is a major thyroid-hormone binding protein involved in transporting thyroxine from the bloodstream to the brain. Prealbumin is located in the cytoplasm and in the vesicles of developing rat brain cells, and is thought to be transported there from the cerebrospinal fluid via endocytosis. Sequence variants of this protein have been identified in amyloid fibrils from patients with familial amyloidotic polyneuropathy (FAP), the most common form of hereditary systemic amyloidosis. Although the biologically active form of Prealbumin is a tetramer, the amyloidogenic intermediate is thought to be a monomeric species. Prealbumin also binds to the retinol carrier protein RBP (retinol-binding protein).

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human full-length protein

Isotype: IgG2

Application Details

Application Notes:

Known_Application: Western Blot (2-4 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human liver.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: TTR

Background: Transthyretin, PALB, HsT2651, prealbumin, amyloidosis type 1, ATTR, TBPA, CTS, CTS1, carpal tunnel syndrome 1, thyroxine-binding prealbumin, prealbumin, HEL111, TTR protein, Epididymis luminal protein 111, prealbumin thyroxine binding, senile systemic amyloidosis antibody,Transthyretin (Prealbumin)
Cellular localisation: Secreted. Cytoplasm.

Molecular Weight: 15kDa

Gene ID: 7276, 427202

UniProt: P02766

Pathways: Hormone Transport