NOC4L antibody

Catalog No. ABIN7127072

The Mouse Monoclonal anti-NOC4L antibody (Clone PCRP-NOC4L-1B2) (ABIN7127072) specifically detects NOC4L in FACS and IF. The antibody is reactive with Human samples.

Quick Overview for NOC4L antibody (ABIN7127072)

Target: NOC4L (Nucleolar Complex Associated 4 Homolog (NOC4L))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NOC4L antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: PCRP-NOC4L-1B2

Product Details anti-NOC4L Antibody

Purpose: Nucleolar complex-associated protein 4-like protein (NOC4L) Antibody

Specificity: Treg activation is critical for maintaining self-tolerance, but the translational control of this process is still poorly understood. Zhu et al. report a conserved ribosome biogenesis factor, Noc4L, that regulates mRNAs related to Treg and Tconv activation but does not affect global protein translation. Noc4L regulates translation of mRNAs related to Treg activation. Noc4L plays critical roles in activation of Tregs and Tconvs. Noc4L-mediated ribosome biogenesis is critical in controlling the activation of Tregs and maintaining immune tolerance. [Zhu et al., 2019, Cell Reports 27, 1205 1220.]

Cross-Reactivity (Details): Human

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human NOC4L protein

Isotype: IgG1

Application Details

Application Notes:

Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or 293T cells.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for NOC4L

Target: NOC4L (Nucleolar Complex Associated 4 Homolog (NOC4L))

Alternative Name: NOC4L

Background:

NOC4 protein homolog, NOC4-like protein, Nucleolar complex protein 4 homolog, Nucleolar complex-associated protein 4-like protein

HeLa or 293T cells.

Molecular Weight: 58.4kDa

Gene ID: 79050, 558536

UniProt: Q9BVI4