INSM2 antibody (AA 432-540)

Catalog No. ABIN7127097

This Mouse Monoclonal antibody specifically detects INSM2 in IHC. It exhibits reactivity toward Human.

Quick Overview for INSM2 antibody (AA 432-540) (ABIN7127097)

Target: INSM2 (Insulinoma-Associated 2 (INSM2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This INSM2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: INSM2-4291

Product Details anti-INSM2 Antibody

Binding Specificity: AA 432-540

Purpose: Insulinoma Associated 2 / INSM2 Antibody

Specificity: IA-6, also known as insulinoma-associated 2 or INSM2, is related to IA-1 (INSM1), a zinc-finger factor that is expressed in the developing nervous system. While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes. The homology exhibited by IA-6 to IA-1 has led to speculation that IA-6 may also play a role in the regulation of gene transcription. INSM2 may function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.

Cross-Reactivity (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human INSM2 protein (around aa 432-540) (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human pancreas tissue.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for INSM2

Target: INSM2 (Insulinoma-Associated 2 (INSM2))

Alternative Name: INSM2

Background:

IA1, Insulinoma associated protein 2 (IA2), Zinc finger protein IA6

Human pancreas tissue.

Molecular Weight: 58kDa

Gene ID: 84684, 62813

UniProt: Q96T92