Recombinant Angiopoietin 2 antibody

Catalog No. ABIN7127339

This Rabbit Monoclonal antibody specifically detects Angiopoietin 2 in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Recombinant Angiopoietin 2 antibody (ABIN7127339)

Target: Angiopoietin 2 (ANGPT2)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Angiopoietin 2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: 1F10

Product Details anti-Angiopoietin 2 Antibody

Cross-Reactivity: Human

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Angiopoietin 2

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Angiopoietin 2

Target: Angiopoietin 2 (ANGPT2)

Alternative Name: ANGPT2

Background:

Background: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Aliases: Angiopoietin-2 (ANG-2), ANGPT2

UniProt: O15123

Pathways: RTK Signaling