Recombinant Menin antibody

Catalog No. ABIN7127614

The Rabbit Monoclonal anti-Menin antibody (Clone 8G11) (ABIN7127614) specifically detects Menin in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for Recombinant Menin antibody (ABIN7127614)

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Menin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 8G11

Product Details anti-Menin Antibody

Purpose: MEN1 Recombinant Monoclonal Antibody

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Menin

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:5000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Menin

Target: Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))

Alternative Name: MEN1

Background:

Background: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

Aliases: Menin, MEN1, SCG2

UniProt: O00255

Pathways: Chromatin Binding, Positive Regulation of Endopeptidase Activity