ACOT8 antibody (AA 31-130)

Catalog No. ABIN708641

The Rabbit Polyclonal anti-ACOT8 antibody has been validated for ELISA, IF (cc), IF (p), IHC (p) and IHC (fro). It is suitable to detect ACOT8 in samples from Human.

Quick Overview for ACOT8 antibody (AA 31-130) (ABIN708641)

Target: ACOT8 (Acyl-CoA Thioesterase 8 (ACOT8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACOT8 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ACOT8 Antibody

Binding Specificity: AA 31-130

Predicted Reactivity: Human,Mouse,Rat,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ACOT8

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ACOT8

Target: ACOT8 (Acyl-CoA Thioesterase 8 (ACOT8))

Alternative Name: ACOT8

Background:

Synonyms: ACTEIII, Acot8, ACOT8_HUMAN, acyl CoA thioesterase 8, Acyl-CoA thioesterase 8, Acyl-coenzyme A thioesterase 8, Choloyl coenzyme A thioesterase, Choloyl-coenzyme A thioesterase, hACTE III, hACTE-III, hACTEIII, HIV Nef associated acyl CoA thioesterase, HIV-Nef-associated acyl-CoA thioesterase, HNAACTE, hTE, Long chain fatty acyl CoA hydrolase, Palmitoyl CoA hydrolase, Peroxisomal acyl CoA thioesterase 1, Peroxisomal acyl coenzyme A thioester hydrolase 1, Peroxisomal acyl-coenzyme A thioester hydrolase 1, Peroxisomal long chain acyl CoA thioesterase 1, Peroxisomal long-chain acyl-CoA thioesterase 1, PTE 1, PTE 2, PTE-1, PTE-2, PTE1, PTE2, Thioesterase II.

Background: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A Thioesterase 8, also known as ACOT8 may mediate Nef-induced down-regulation of CD4. It is a major thioesterase in peroxisomes and competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). It shows a preference for medium-length fatty acyl-CoAs and may be involved in the metabolic regulation of peroxisome proliferation.

Gene ID: 10005

Pathways: Monocarboxylic Acid Catabolic Process