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IGSF6 antibody

IGSF6 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7129823
  • Target See all IGSF6 Antibodies
    IGSF6 (Immunoglobulin Superfamily, Member 6 (IGSF6))
    Reactivity
    • 30
    • 1
    • 1
    Human
    Host
    • 27
    • 3
    Rabbit
    Clonality
    • 29
    • 1
    Polyclonal
    Conjugate
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IGSF6 antibody is un-conjugated
    Application
    • 19
    • 17
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    Antigen affinity purification
    Immunogen
    Fusion protein of Human IGSF6
    Isotype
    IgG
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    Discover our top product IGSF6 Primary Antibody
  • Application Notes
    ELISA:1:1000-1:5000, IHC:1:5-1:20,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    IGSF6 (Immunoglobulin Superfamily, Member 6 (IGSF6))
    Alternative Name
    IGSF6 (IGSF6 Products)
    Synonyms
    IGSF6 antibody, DORA antibody, immunoglobulin superfamily member 6 antibody, immunoglobulin superfamily, member 6 antibody, IGSF6 antibody, Igsf6 antibody
    Background

    Background: IGSF6 (DORA), a novel member of the immunoglobulin superfamily (IGSF) from human and rat expressed in dendritic and myeloid cells. Using a probe from the open reading frame of the rat cDNA, we isolated a cosmid which contains the entire mouse gene. By comparative analysis and reverse transcriptase polymerase chain reaction, we defined the intron/exon structure and the mRNA of the mouse gene and, with respect to human BAC clones, the human gene. The genes span 10 kb (mouse) and 12 kb (human), with six exons arranged in a manner similar to other members of the IGSF. All intron/exon boundaries follow the GT-AG rule. Expression of the mouse Igsf6 gene is restricted to cells of the immune system, particularly macrophages. Northern blot revealed a single mRNA of 2.5 kb, in contrast to the human gene which is expressed as two mRNAs of 1 and 2.5 kb. The human and mouse genes were localized to a locus associated with inflammatory bowel disease. Analysis of the flanking regions of the Igsf6 gene revealed the presence of an unrelated gene, transcribed from the opposite strand of the DNA and oriented such that the Igsf6 gene is encoded entirely within an intron. An identical organization is seen in human.

    Aliases: Donwregulated by activation gene antibody, DORA antibody, Down regulated by activation (immunoglobulin superfamily) antibody, IgSF6 antibody, IGSF6_HUMAN antibody, Immunoglobulin superfamily member 6 antibody, Protein DORA antibody

    UniProt
    O95976
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