PCP4 antibody

Catalog No. ABIN7130557

Product Details anti-PCP4 Antibody

Target: PCP4 (Purkinje Cell Protein 4 (PCP4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCP4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Cross-Reactivity: Human, Mouse, Rat

Purification: Antigen affinity purification

Immunogen: Fusion protein of Human PCP4

Isotype: IgG

Application Details

Application Notes: ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:5-1:20,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PCP4

Target: PCP4 (Purkinje Cell Protein 4 (PCP4))

Alternative Name: PCP4 (PCP4 Products)

Synonyms: PEP-19 antibody, P16Rimb19 antibody, Pcp-4 antibody, Pep19 antibody, PEPZ19 antibody, pep-19 antibody, Purkinje cell protein 4 antibody, PCP4 antibody, Pcp4 antibody

Background:

Background: PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Aliases: Brain specific antigen PCP 4 antibody, Brain specific polypeptide PEP 19 antibody, Brain specific polypeptide PEP19 antibody, Brain-specific antigen PCP-4 antibody, Brain-specific polypeptide PEP-19 antibody, OTTHUMP00000109191 antibody, Pcp4 antibody, PCP4_HUMAN antibody, PEP19 antibody, Purkinje cell protein 4 antibody

UniProt: P48539