HSPG2 antibody (AA 3601-3700)

Catalog No. ABIN709256

The Rabbit Polyclonal anti-HSPG2 antibody has been validated for ELISA, IHC (p), FACS, IHC (fro), IF (cc) and IF (p). It is suitable to detect HSPG2 in samples from Human.

Quick Overview for HSPG2 antibody (AA 3601-3700) (ABIN709256)

Target: HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSPG2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HSPG2 Antibody

Binding Specificity: AA 3601-3700

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Heparan Sulfate Proteoglycan 2

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for HSPG2

Target: HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))

Alternative Name: Heparan Sulfate Proteoglycan 2

Background:

Synonyms: Perlecan, Basement membrane specic heparan sulfate proteoglycan core protein, Endorepellin domain V region, Heparan Sulfate Proteoglycan, Heparan sulfate proteoglycan of basement membrane, HSPG 2, HSPG, Hspg2, LG3 peptide, Perlecan, PLC antibody Schwartz Jampel syndrome 1 chondrodystrophic myotonia, SJA antibody SJS antibody SJS1 antibody.

Background: This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans(heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010].

Gene ID: 117194

Pathways: Glycosaminoglycan Metabolic Process, Lipid Metabolism