TWIST2 antibody

Catalog No. ABIN7138153

Product Details anti-TWIST2 Antibody

Target: TWIST2 (Twist Homolog 2 (TWIST2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TWIST2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Peptide sequence around aa.26~30(P-K-R-F-G) derived from Human Twist2.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TWIST2

Target: TWIST2 (Twist Homolog 2 (TWIST2))

Alternative Name: TWIST2 (TWIST2 Products)

Synonyms: TWIST2 antibody, DERMO1 antibody, FFDD3 antibody, SETLSS antibody, bHLHa39 antibody, Dermo1 antibody, CDERMO-1 antibody, twist family bHLH transcription factor 2 antibody, twist basic helix-loop-helix transcription factor 2 antibody, TWIST2 antibody, Twist2 antibody

Background:

Background:

Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.

Lee M.S., Lowe G., Flanagan S., Kuchler K., Glackin C.A.Bone 27:591-602(2000)

Aliases: bHLHa39 antibody, Class A basic helix-loop-helix protein 39 antibody, Dermis expressed protein 1 antibody, Dermis-expressed protein 1 antibody, DERMO 1 antibody, Dermo-1 antibody, DERMO1 antibody, MGC117334 antibody, Twist 2 antibody, Twist homolog 2 (Drosophila) antibody, Twist homolog 2 antibody, Twist related bHLH protein Dermo1 antibody, Twist related protein 2 antibody, Twist-related protein 2 antibody, Twist2 antibody, TWST2_HUMAN antibody

UniProt: Q8WVJ9

Pathways: Chromatin Binding