IRS1 antibody (pSer312)

Catalog No. ABIN7138549

This anti-IRS1 antibody is a Rabbit Polyclonal antibody detecting IRS1 in WB and ELISA. Suitable for Human.

Quick Overview for IRS1 antibody (pSer312) (ABIN7138549)

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IRS1 Antibody

Binding Specificity: pSer312

Cross-Reactivity: Human, Mouse, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Peptide sequence around phosphorylation site of serine 312 (A-T-S(p)-P-A) derived from Human IRS-1.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IRS1

Target: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Alternative Name: IRS1

Background:

Background: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

Tzatsos A, et al. (2006) Mol Cell Biol, 26(1): 63-76
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A, 98(8): 4640-4645
Szanto I, et al. (2000) Proc Natl Acad Sci U S A, 97(5): 2355-2360
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A, 98(8): 4640-4645

Aliases: HIRS 1 antibody, HIRS1 antibody, Insulin receptor substrate 1 antibody, IRS 1 antibody, IRS-1 antibody, IRS1 antibody, IRS1_HUMAN antibody, OTTHUMP00000164234 antibody

UniProt: P35568

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process