APH1B antibody (AA 93-110)

Catalog No. ABIN7139847

The Rabbit Polyclonal anti-APH1B antibody is suitable to detect APH1B in samples from Human. It has been validated for WB and ELISA.

Quick Overview for APH1B antibody (AA 93-110) (ABIN7139847)

Target: APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APH1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-APH1B Antibody

Binding Specificity: AA 93-110

Purpose: APH1B Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Peptide sequence from Human Gamma-secretase subunit APH-1B protein (93-110AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for APH1B

Target: APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))

Alternative Name: APH1B

Background:

Background: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.

Aliases: Anterior pharynx defective 1 homolog B (C. elegans) antibody, Anterior pharynx defective 1 homolog B antibody, Anterior pharynx defective 1B like antibody, Anterior pharynx defective 1b short splicing variant antibody, APH 1B antibody, Aph 1beta antibody, APH-1b antibody, Aph-1beta antibody, Aph1 beta antibody, aph1b antibody, APH1B_HUMAN antibody, Aph1beta antibody, DKFZp564D0372 antibody, Gamma secretase subunit APH 1B antibody, Gamma secretase subunit APH1B antibody, Gamma secretase sununit antibody, Gamma-secretase subunit Aph-1b antibody, Presenilin stabilisation factor like antibody, Presenilin-stabilization factor-like antibody, PRO 1328 antibody, PRO1328 antibody, PSFL antibody, TAAV 688 antibody, TAAV688 antibody

UniProt: Q8WW43

Pathways: Notch Signaling, Neurotrophin Signaling Pathway