PEN2 antibody (AA 39-57) (HRP)

Catalog No. ABIN7139854

This anti-PEN2 antibody is a Rabbit Polyclonal antibody detecting PEN2 in ELISA. Suitable for Human.

Quick Overview for PEN2 antibody (AA 39-57) (HRP) (ABIN7139854)

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEN2 antibody is conjugated to HRP

Application: ELISA

Product Details anti-PEN2 Antibody (HRP)

Binding Specificity: AA 39-57

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Peptide sequence from Human Gamma-secretase subunit PEN-2 protein (39-57AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Alternative Name: PSENEN

Background:

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).

Aliases: Gamma secretase subunit PEN 2 antibody, Gamma Secretase Subunit PEN2 antibody, Gamma-secretase subunit PEN-2 antibody, Hematopoietic stem/progenitor cells protein MDS033 antibody, MDS033 antibody, MSTP064 antibody, PEN 2 antibody, PEN2_HUMAN antibody, Presenilin Enhancer 2 antibody, Presenilin enhancer 2 homolog antibody, Presenilin enhancer protein 2 antibody, PSEN2 antibody, psenen antibody

UniProt: Q9NZ42

Pathways: Notch Signaling, Neurotrophin Signaling Pathway