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IgG3 antibody (AA 312-324) (Biotin)

Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7139884
  • Target See all IgG3 Antibodies
    IgG3
    Binding Specificity
    • 3
    • 1
    AA 312-324
    Reactivity
    Human
    Host
    • 4
    • 1
    Rabbit
    Clonality
    • 4
    • 1
    Polyclonal
    Conjugate
    • 3
    • 1
    • 1
    This IgG3 antibody is conjugated to Biotin
    Application
    • 3
    • 2
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Peptide sequence from Human Immunoglobulin heavy constant gamma 3 protein (312-324AA)
    Isotype
    IgG
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  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    IgG3
    Alternative Name
    IGHG3 (IgG3 Products)
    Synonyms
    IgG3 antibody, Immunoglobulin heavy constant gamma 3 antibody, immunoglobulin heavy constant gamma 3 (G3m marker) antibody, Ighg3 antibody, IGHG3 antibody
    Target Type
    Antibody
    Background

    Background: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

    Aliases: IGHG3Immunoglobulin heavy constant gamma 3 antibody, HDC antibody, Heavy chain disease protein antibody, Ig gamma-3 chain C region antibody

    UniProt
    P01860
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