CSK antibody

Catalog No. ABIN7140312

Product Details anti-CSK Antibody

Target: CSK (C-Src tyrosine Kinase (CSK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CSK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Cross-Reactivity: Human, Rat

Purification: Affinity purified

Immunogen: Purified recombinant human CSK protein fragments expressed in E.coli.

Isotype: IgG2b

Application Details

Application Notes: Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine( pH 7.4,150 mM NaCl)with 0.2 % sodium azide,0.1 mg/mLBSA and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CSK

Target: CSK (C-Src tyrosine Kinase (CSK))

Alternative Name: CSK (CSK Products)

Synonyms: AW212630 antibody, C-terminal Src kinase antibody, c-src tyrosine kinase antibody, CSK, non-receptor tyrosine kinase antibody, CSK antibody, Csk antibody

Background:

Background: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Aliases: C SRC, C SRC kinase, C src Tyrosine Kinase, C-SRC kinase, c-src tyrosine kinase, Csk A, CSK, CSK_HUMAN, CYTOPLASMIC TYROSINE KINASE, EC2.7.10.2, MGC112926, MGC117393, MGC154049, P60 Src, Protein tyrosine kinase CYL, Protein-tyrosine kinase CYL,

UniProt: P41240

Pathways: TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events