RPA1 antibody

Catalog No. ABIN7140348

The Mouse Monoclonal anti-RPA1 antibody is suitable to detect RPA1 in samples from Human. It has been validated for WB, ELISA, IP and ICC.

Quick Overview for RPA1 antibody (ABIN7140348)

Target: RPA1 (Replication Protein A1, 70kDa (RPA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RPA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC)

Product Details anti-RPA1 Antibody

Purpose: RPA1 Monoclonal Antibody

Cross-Reactivity: Monkey, Mouse, Rat

Purification: Affinity purified

Immunogen: Purified recombinant human RPA70 protein fragments expressed in E.coli.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified mouse monoclonal antibody in PBS( pH 7.4) containing with 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RPA1

Target: RPA1 (Replication Protein A1, 70kDa (RPA1))

Alternative Name: RPA1

Background:

Background: Plays an essential role in several cellular processes in DNA metabolism including replication,recombination and DNA repair.Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.Functions as component of the alternative replication protein A complex (aRPA).aRPA binds single-stranded DNA and probably plays a role in DNA repair,it does not support chromosomal DNA replication and cell cycle progression through S-phase.In vitro,aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC),the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.

Aliases: Dmrpa1, Drosophila Replication Protein A, DRPA, HSSB, Human single stranded DNA binding protein, MST075, MSTP075, p70, REPA1, Replication factor A, Replication factor A protein 1, Replication protein A 70 kDa DNA-binding subunit,

UniProt: P27694

Pathways: Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA