CRP antibody (AA 1-210) (Biotin)

Catalog No. ABIN7141407

The Rabbit Polyclonal anti-CRP antibody has been validated for ELISA. It is suitable to detect CRP in samples from E. coli.

Quick Overview for CRP antibody (AA 1-210) (Biotin) (ABIN7141407)

Target: CRP (C-Reactive Protein (CRP))

Reactivity: E. coli

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRP antibody is conjugated to Biotin

Application: ELISA

Product Details anti-CRP Antibody (Biotin)

Binding Specificity: AA 1-210

Cross-Reactivity: E. coli

Purification: >95%, Protein G purified

Immunogen: Recombinant Escherichia coli cAMP-activated global transcriptional regulator CRP protein (1-210AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CRP

Target: CRP (C-Reactive Protein (CRP))

Alternative Name: crp

Background:

Background: A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5\'-AAATGTGATCTAGATCACATTT-3\') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters, class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site overlap, CRP making multiple contacts with RNAP. Class III promoters require multiple activator molecules, including at least one CRP dimer. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA (about 87 degrees), bringing upstream promoter elements into contact with RNAP. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. High levels of active CRP are detrimental to growth.Plays a major role in carbon catabolite repression (CCR). CCR involves cAMP, adenylate cyclase (cyaA), CRP and the EIIA-Glc component of the PTS (crr). In the presence of glucose EIIA-Glc is dephosphorylated, and does not activate adenylate cyclase, leading to reduced cAMP and thus decreased CRP activity. Also plays a role in many other processes

Aliases: crp antibody, cap antibody, csm antibody, b3357 antibody, JW5702cAMP-activated global transcriptional regulator CRP antibody, Catabolite activator protein antibody, CAP antibody, Catabolite gene activator antibody, cAMP receptor protein antibody, CRP antibody, cAMP regulatory protein antibody

UniProt: P0ACJ8

Pathways: Carbohydrate Homeostasis