CYP27B1 antibody (AA 350-491) (Biotin)

Catalog No. ABIN7142191

The Biotin-conjugated Rabbit Polyclonal anti-CYP27B1 antibody (ABIN7142191) specifically detects CYP27B1 in ELISA. The antibody is reactive with Human samples.

Quick Overview for CYP27B1 antibody (AA 350-491) (Biotin) (ABIN7142191)

Target: CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP27B1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-CYP27B1 Antibody (Biotin)

Binding Specificity: AA 350-491

Purpose: CYP27B1 Antibody, Biotin conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial protein (350-491aa)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CYP27B1

Target: CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))

Alternative Name: CYP27B1

Background:

Background: Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)(2)D3), and of 24,25-dihydroxyvitamin D3 (24,25(OH)(2)D3) to 1-alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)(3)D3). Is also active with 25-hydroxy-24-oxo-vitamin D3. Plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.

Aliases: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (EC 1.14.15.18) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (Calcidiol 1-monooxygenase) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome P450C1 alpha) (Cytochrome P450VD1-alpha) (Cytochrome p450 27B1), CYP27B1, CYP1ALPHA CYP27B

UniProt: O15528

Pathways: Metabolism of Steroid Hormones and Vitamin D